Proteinase 3: the odd one out that became an autoantigen

Identity of Wegener's autoantigen (p29) with proteinase 3 and myeloblastin.

Proteinase 3, Wegener's autoantigen: from gene to antigen.

Proteinase 3 (PR3) is one of four serine protease homologues in the azurophilic granules of neutrophils and granules of monocytes. It is of importance that anti-neutrophil cytoplasmic antibodies (ANCA) in patients with Wegener's granulomatosis (WG) are mainly directed against PR3 only. Furthermore, PR3 is overexpressed in a variety of acute and chronic myeloid leukemia cells. Cytotoxic T lympho...

The Odd One Out: Identifying and Characterising Anomalies

In many situations there exists an abundance of positive examples, but only a handful of negatives. In this paper we show how in binary or transaction data such rare cases can be identified and characterised. Our approach uses the Minimum Description Length principle to decide whether an instance is drawn from the training distribution or not. By using frequent itemsets to construct this compre...

Antimicrobial Resistance in Mycobacterium tuberculosis: The Odd One Out.

Antimicrobial resistance (AMR) threats are typically represented by bacteria capable of extensive horizontal gene transfer (HGT). One clear exception is Mycobacterium tuberculosis (Mtb). It is an obligate human pathogen with limited genetic diversity and a low mutation rate which lacks any evidence for HGT. Such features should, in principle, reduce its ability to rapidly evolve AMR. We identif...

Fractally Finding the Odd One Out: An Analogical Strategy For Noticing Novelty

The Odd One Out test of intelligence consists of 3x3 matrix reasoning problems organized in 20 levels of difficulty. Addressing problems on this test appears to require integration of multiple cognitive abilities usually associated with creativity, including visual encoding, similarity assessment, pattern detection, and analogical transfer. We describe a novel fractal strategy for addressing vi...